ncRNA name | RhoA shRNA |
ncRNA Category | shRNA |
Disease name | optic nerve injury |
Species | Rattus norvegicus |
Tissues/Cell_line | retinas, optic nerves |
Methods | Western blot, shRNA injection, histology and immunohistochemistry |
Expression pattern | associated |
Functional description | AAV-RhoA shRNA decreased RhoA expression levels and promoted neurite outgrowth in vitro. In the ONC model, AAV-RhoA shRNA by itself had only weak beneficial effects on RGC axon regeneration. However, when combined with AAV-CNTF, AAV-RhoA shRNA significantly improved the therapeutic effect of AAV-CNTF on axon regeneration by nearly two fold. |
PubMed ID | 28017835 |
Year | 2017 |
Title | AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration. |
Drug-related ncRNA | NA |
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